Interplay between protein domains in the liquid-liquid phase separation of FOXP2
Marco Dell'Oca, Serena Vaglietti, Stefania Boggio Bozzo, Ferdinando Fiumara · FENS Forum 2024
The transcription factor FOXP2 is a regulator of vocalization-, speech-, and language-related phenotypes in human and non-human species. The FOXP2 protein contains multiple domains including a DNA-binding forkhead domain, a zinc finger domain, a leucine zipper, and N-terminal polyglutamine (polyQ) repeats. We have recently found that the FOXP2 N-terminal polyQ region drives the liquid-liquid phase separation (LLPS) of the protein. FOXP2 LLPS is regulated by the evolutionary length variation of the polyQ repeats and has a role in modulating the transcriptional activity of the protein. The poten
ePoster · Neuroscience