Epitranscriptomic regulation of synaptic plasticity via novel pharmacological tools
Rahaf Keskinen, Joni Haikonen, Sari Lauri · FENS Forum 2024
N6-methyladenosine (m6A) methylation, the most prevalent eukaryotic mRNA modification, is enriched in the mammalian brain and the synaptic transcriptome. m6A methylation is dynamically regulated by enzymes called m6A writers (METTL3/14) and erasers (FTO), that are present in distal neuronal processes. Although recent studies link dynamic m6A methylome changes during synaptic plasticity to memory consolidation, the exact mechanisms in neuronal circuits remain unclear. This study investigates m6A methylation effects on synaptic transmission and plasticity within hippocampal networks, utilizing p
ePoster · Neuroscience