ePoster · Neuroscience
The effect of altered ganglioside composition on leptin receptor and Na⁺,K⁺-ATPase in mouse thalamus
Vinka Potočki, Borna Puljko, Nikolina Maček Hrvat, Marta Balog, Marija Heffer, Svjetlana Kalanj Bognar, Kristina Mlinac Jerković · FENS Forum 2024
Gangliosides, complex membrane glycosphingolipids, engage in a variety of inter- and intracellular interactions, and play a crucial role in the pathogenesis of various neurological and neurodegenerative diseases. Another membrane constituent, leptin receptor (LepR), modulates feeding behavior by influencing signaling and integration in many regions of the central nervous system. Studies show that a-series gangliosides alter leptin activity by interacting with LepR The redistribution of gangliosides can also influence the regulation of the Na⁺,K⁺-ATPase (NKA) function, whereas leptin pathways c