Interneurons in the nucleus accumbens alter their electrophysiological properties in a mouse model of neuropathic pain
Ilaria Sanvido, Marie-Luise Edenhofer, Theodora Kalpachidou, Kai K. Kummer · FENS Forum 2024
Recently, research has focused extensively on the peripheral mechanisms that contribute to pain chronification, but our knowledge on the involvement of different brain regions remains limited. The Nucleus Accumbens (NAc) is a central hub for reward-related processes, with its interneurons having significant potential to control NAc output signals. However, their involvement in the chronification of pain has not been investigated until now.In this study, we performed patch-clamp recordings of cholinergic interneurons (ChIs) and GABAergic interneurons positive for parvalbumin (PV-GaIs) and somat
ePoster · Neuroscience