Unraveling the role of NALCN in neural circuit development
Candela Barettino, Álvaro Ballesteros-González, Hiromasa Funato, Masashi Yanagisawa, Dejian Ren, Leszek Lisowski, Stephan Pless, Antonio Gil-Nagel, Arnaud Monteil, Isabel Del Pino · FENS Forum 2024
The sodium (Na+)-leak channel (NALCN) maintains neuronal resting membrane potential by conducting a sodium leak current. Pathogenic mutations in the NALCN channelosome complex (NALCN-UNC80-UNC79) are linked to rare developmental and epileptic encephalopathies. However, despite the prevalence of cognitive deficits in NALCN-related disorders, the precise role of NALCN in brain development remains elusive. To address this gap, we investigated the contribution of Nalcn to cortical neural circuit formation using mouse models. Employing Nalcn-GFP reporter mice in conjunction with immunohistochemistr
ePoster · Neuroscience