TrkB receptor interacts with mGlu2 receptor and mediates antipsychotic-like effects of mGlu2 receptor activation in the mouse
Clémentine Philibert, Candice Disdier, Pierre-André Lafon, Alexandre Bouyssou, Mathieu Oosterlaken, Sonya Galant, Anne Pizzoccaro, Pola Tuduri, Jeanne Ster, Jianfeng Liu, Julie Kniazeff, Jean-Philippe Pin, Philippe Rondard, Philippe Marin, Franck Vandermoere · FENS Forum 2024
Metabotropic glutamate receptor 2 (mGlu2) attracts particular attention as a possible target for a new class of antipsychotics. However, the signaling pathways transducing the effects of mGlu2 in the brain remain poorly characterized. In a recent article published in Sciences Advances (doi/10.1126/sciadv.adg1679), we addressed this issue by identifying native mGlu2 interactome in mouse prefrontal cortex. Nanobody-based affinity purification and mass spectrometry identified 149 candidate mGlu2 partners, including the neurotrophin receptor TrkB. The later interaction was confirmed both in cultur
ePoster · Neuroscience