Disrupted nanoscale organization of GABAB receptors and CaV2.1 channels in the hippocampus of APP/PS1 mice
Carolina Aguado, Alejandro Martín-Belmonte, Rocío Alfaro-Ruiz, Ana Esther Moreno-Martínez, Miriam Fernández, María Llanos Martínez-Poyato, Ricardo Alfonso Puertas-Avendaño, Yugo Fukazawa, Rafael Luján · FENS Forum 2024
Voltage-gated CaV2.1 Ca2+ channels play a crucial role in regulating neurotransmitter release, thus contributing to processes such as learning and memory. Despite their recognised importance in neural function, there is limited information on their potential involvement in neurodegenerative conditions such as Alzheimer's disease (AD). Aims: to explore the impact of amyloid-β (Aβ) pathology on the nanoscale compartmentalization of CaV2.1-GABAB in the hippocampus.Methods: We used histoblot and SDS-digested freeze-fracture replica labelling (SDS-FRL) techniques in the CA1 field of the hippocampus
ePoster · Neuroscience