Does spreading depression rewire cortical pain networks?
Bengisu Solgun, Buket Nebiye Demir, Hulya Karatas Kursun, Sefik Evren Erdener · FENS Forum 2024
Aims: Resting-state functional imaging (RSFI) is increasingly used to understand how distinct brain networks modulate and respond to pain. As migraine, a common headache disorder, can be experimentally modeled by triggering cortical spreading depolarizations (CSD) in rodents, it is crucial to understand its impact on network connectivity to find imaging markers for experimental evaluation of headache and trigeminovascular activation. We used wide-field intrinsic optical-signal imaging (IOSI) to investigate the impact of CSDs on bihemispheric RSFI connectivity. Methods: C57BL6-ChR2mice underwen
ePoster · Neuroscience