Temporal regulation of voltage-gated sodium channels by miRNAs during hippocampal development: Insights from Argonaute sequencing
Petra Bencurova, Albert Sanfeliu, Gary Brennan, David Henshall · FENS Forum 2024
Voltage-gated sodium channels (Navs) play an integral role in brain function and development, enabling the generation and transmission of electrical signals with implications for neuronal excitability, synapse formation, and circuit establishment. Despite the distinct spatiotemporal expression of Navs, the understanding of their regulation in the developing brain is limited. Here we investigated the involvement of microRNAs (miRNAs), short non-coding RNAs, in the post-transcriptional regulation of sodium channel subunit expression. We carried out Argonaute sequencing on mouse hippocampal tissu
ePoster · Neuroscience