Topic: NDNFIs

The Dentate Gyrus (DG) receives rich multimodal inputs from the entorhinal cortex through the perforant path, and it translates them into a sparse code for the CA3. During the exploration of new environments, groups of DG granule cells (GCs) become active and form new memories. The activity of GCs is strongly modulated by a large network of inhibitory interneurons (INs) that allow the sparsification and orthogonalization of cortical inputs. Recently, a novel population of GABAergic INs expressing the Neuron-Derived Neutrophic Factor (NDNFIs) has been identified as a key component in the modula