Topic: neocortical-hippocampal-neocortical loop

During NREM sleep, the brain is in a self-organized excitable regime in which alternations between spiking and near cessation of spiking propagate along the forebrain, termed slow oscillations (SOs) or UP and DOWN states in the neocortex, and sharpwave-ripples (SPW-Rs) in the hippocampus (Levenstein 2019). Both gain and loss of function studies have demonstrated the importance of tight temporal coordination between SOs and SPW-Rs for systems consolidation. However, where and how this coordination is spontaneously achieved is unknown, despite being essential for understanding whole-brain mechan