Human brain ECM: From morphogenetic role to specification of cortical microcircuitries
Natasa Jovanov Milosevic, Mihaela Bobic Rasonja, Marija Milkovic Perisa, Ivan Banovac, Sara Trnski Levak, Matea Drlje Curt, Andrija Štajduhar, Ivana Pogledic, Goran Sedmak, Zdravko Petanjek · FENS Forum 2024
The brain extracellular matrix (ECM) provides a physical framework and biochemical milieu for early (embryonic) morphogenetic and later (fetal and neonatal) histogenetic events. The specific ECM constituents and their dynamic spatial and temporal distribution at transcriptomics and protein levels were researched using RNAseq analysis and immunohistochemistry in 200 postmortem fetal and postnatal human brains. The ECM is especially prominent in the transiently voluminous histogenetic zones such as the neocortical preplate, subplate, and marginal zone. Still, it is also present in the smaller de
ePoster · Neuroscience