Neocortical long-range inhibitory neurons coordinate state-dependent network synchronization and promote sleep
Geoffrey Terral, Jacob Ratliff, Jaime Heiss, Arenski Vazquez Lechuga, Julie Mota, Charu Ramakrishnan, Lief Fenno, Karl Deisseroth, Thomas Kilduff, Renata Batista-Brito · FENS Forum 2024
Arousal states, such as sleep and wake, are highly correlated with specific rhythmic activity patterns in the neocortex. For example, during sleep, neocortical rhythms are synchronized and dominated by low-frequency oscillations. Recent evidence suggests that inhibitory neurons (INs) are key regulators of neocortical states.Here we investigate how neocortical long-range INs that co-express somatostatin (SST) and neuronal nitric oxide synthase (nNOS) (“SST/nNOS cells”), control patterns of synchronous neocortical activity and arousal states in mice. While the in-vivo function of SST/nNOS cells
ePoster · Neuroscience