Clemastine-induced myelination promotes motor recovery in the neonatal hypoxic ischemia rat
Taichi Goto, Tomokazu Tsurugizawa, Yuji Komaki, Sunao Iwaki, Ichiro Takashima, Nobuo Kunori · FENS Forum 2024
Neonatal hypoxic ischemia (HI) causes motor impairment affecting daily activity. Rehabilitation is frequently implemented to improve motor performance, but its effects are often insufficient for acquiring fine motor coordination. Recently, myelin plasticity has been pointed out necessary for improving motor skills. However, the significance of myelination for motor improvement after HI remains unclear.To address this issue, we investigated the effect of rehabilitation exercise on myelination in a neonatal HI rat model. We then examined the effectiveness of pharmacological promotion of myelinat
ePoster · Neuroscience