Topic: nerve-derived EVs

The dynamics of biological systems depend on complex cell-cell interactions. Extracellular vesicles (EVs) are nanosized vehicles of intercellular communication which shuttle several molecules from cell to cell, thus influencing relevant biological processes. Previous literature based on EV isolation from cell culture medium highlighted how EVs in the peripheral nervous system could be important mediators in the molecular dialogue between neurons and Schwann cells. Here, we aim to extract EVs directly from peripheral nerve tissue, as this would give the unique opportunity to characterize EVs fr