NGF-sensitive interpeduncular nucleus (IPN) neurons in circuits shaping social behaviour: Anatomical and functional studies of the nucleus incertus–IPN–ventral hippocampus axis
Sylwia Drabik, Aleksandra Trenk, Gugula Anna, Sambak Patryk, Kaleta Angelika, Stopka Gabriela, Mohammed Akhter Hossain, Andrew L. Gundlach · FENS Forum 2024
The interpeduncular nucleus (IPN) is a highly complex and evolutionarily conserved midbrain locus involved in social novelty preference and anxiety control. The IPN is characterised by a high density of the nerve-growth factor (NGF) receptor, TrkA; and notably, social stress strongly promotes brain NGF synthesis. The IPN is densely innervated by the nucleus incertus (NI), a stress-sensitive region that is the primary source of the neuropeptide, relaxin-3 (RLN3). In turn, IPN innervates the ventral hippocampus (vHPC), another key locus for social behaviour and anxiety control. However, the natu
ePoster · Neuroscience