Topic: network robustness

Persistent neural activity underlies key cognitive functions like short-term memory. To support persistent neural activity, circuits must learn to balance recurrent amplification (prolonging network time constants) with sufficient robustness to gate out perturbations in local parts of the network. It remains unclear how such persistent and robust representations emerge in neural circuits. Neurons in the mouse anterior lateral motor cortex (ALM) exhibit preparatory activity during motor planning, a robust persistent activity maintained by both hemispheres. We used longitudinal two-photon calciu