ECM remodeling by ADAMTS5 is crucial for inactivity-induced homeostatic plasticity mechanisms
Bartomeu Perelló Amorós, Ezgi Erterek, Sara Parsa, Sonja Menge, Fabian Zmiskol, Aneta Petrušková, Debarpan Guhathakurta, Enes Yagiz Akdas, Rahul Kaushik, Alexander Dityatev, Anna Fejtová, Renato Frischknecht · FENS Forum 2024
Synaptic homeostatic plasticity maintains firing of neuronal networks within physiological range, by adjusting synaptic strength via molecular and morphological changes in the synapse. The perineuronal extracellular matrix (ECM), which is mainly composed of chondroitin sulfate proteoglycans such as brevican, stabilizes synapses and reduces their plasticity. Previous data indicated that brevican is cleaved during homeostatic plasticity, which may facilitate synapse remodeling. The proteases ADAMTS4, -5 and the closely related ADAMTS8 and -15 may share brevican as substrate for ECM regulation. T
ePoster · Neuroscience