Exploring the impact of partial reprogramming on astrocyte biology and its implications for brain homeostasis and aging
Pablo Rodríguez Cumbreras, Xavier d'Anglemont de Tassigny, Fernando Cala Fernández, Camilo José Morado Díaz, Ricardo Pardal Redondo, Francisco Manuel Vega Moreno, Benedikt Berninger, Aida Platero Luengo · FENS Forum 2024
In order to address the limited regenerative capacity of the mammalian brain and the challenges posed by aging-related neurological disorders, we harness reprogramming technology, focusing specifically on neural cell rejuvenation through transient expression of the 4 Yamanaka Factors (4Fs). As the brain ages and undergoes cognitive decline, homeostatic loss and neuroinflammation, our project focuses on the potential of partial reprogramming (PR) to reshape the epigenetic landscape, offering a promising avenue for cellular rejuvenation. We focus primarily on astrocytes, fundamental cells that c
ePoster · Neuroscience