Topic: neural circuit remodeling

Stable neural ensembles are often thought to underlie stable learned behaviors and memory. Recent longitudinal experiments, however, that tracked the activity of the same neurons over days to weeks have shown that neuronal activity patterns can change over extended timescales even if behaviors remain the same – a phenomenon termed representational drift. Here we test whether neural circuit remodeling (defined as any change in structural connectivity) contributes to representational drift. To do this, we tracked how hippocampal CA1 spatial representations of a familiar environment change with t