ePoster · Neuroscience
VSX1 expression in V2 precursor cells at embryological stages could be used to follow spared V2 interneurons after a traumatic injury in adulthood
Ana Dominguez Bajo, Andrea Angla, Guillaume Van Lint, Benoît Derneden, Stéphanie Debrulle, Frédéric Clotman · FENS Forum 2024
Which specific ventral spared interneuron populations take part in spinal tissue reorganization after a traumatic injury (TSCI) has not been clarified yet. We hypothesize that these cells could reactivate developmental processes to be able to form new connections, and that this process could help us to characterize them after lesion. qPCR results indicated a potential re-expression of the transcription factor Vsx1, (which in a normal situation is transiently expressed at early embryonic stages in an intermediate V2 interneurons compartment and absent in the adult spinal cord) 2 weeks after TSC