Neural manifold

…look to population-level features of neural activity and the distributed computations they enable. Here, we focus on two such features: 1) a continuous neural manifold that maps spatial and task structure, 2) spatial representations that “sweep” ahead of the animal as it moves through the en

…Chung introduced a “neural manifold” framework to capture how high-dimensional neural activity is structured into meaningful manifolds reflecting object representations. She demonstrated that manifold geometry—shaped by radius, dimensionality, and correlations—directly governs a population’s capacity for classifying or separating stimuli under nuisance variations. Applying these ideas as a data analysis

Two perspectives can be distinguished in computational neuroscience towards understanding the link between neuronal activity and behaviour.$^1$ On the one hand, focusing on single-neuron responses highlighted that a few functional properties, such as neuronal tuning$^2$ or selectivity,$^3$ often characterise individual responses. These properties determine each neuron's “position” in an abstract space, which we call the “(functional) similarity space”: for example, each cell's preferred head direction (HD) in the mouse HD system determines its position on an abstract ring.$^4$ It is commonly h

During navigation, animals dynamically create rich representations of the environment, forming personalized cognitive maps. The hippocampal area CA1 features spatial cells that adapt based on behavior and internal states. Computational models have usually obtained spatial tuning by training a deep recurrent network for solving path integration, over numerous epochs, using backpropagation [1, 2, 3]. However, such methods do not closely align with the real-time local learning used by animals. Additionally, the formed spatial maps are solely oriented towards solving a specific task, and fail to c

…rely on an attractive neuronal manifold, or cognitive map, in CA3, with topological correspondence to space. Supporting this idea, continuous attractor neural networks (CANNs) show place cell-like tuning for spatial locations, and can be used to simulate plausible trajec

Understanding how the brain builds maps of novel environments on behavioral timescales (seconds-minutes) is a fundamental question for neuroscience. Theoretical works posit a Hebbian plasticity mechanism for integrating novel landmarks [1]. Drosophila have been shown to use such a mechanism to integrate novel landmarks on timescales of minutes [2,3]. However, current evidence suggests that plasticity in the medial entorhinal cortex (MEC) operates on the timescale of days [4] — leaving open the question of how the mammalian brain maps novel environments on behavioral timescales. Here we investi

Brain-computer interfaces (BCIs) have afforded paralysed users “mental control” of computer cursors and robots, and even of electrical stimulators that reanimate their own limbs. Most existing BCIs map the activity of hundreds of motor cortical neurons recorded with implanted electrodes into control signals to drive these devices. Despite these impressive advances, the field is facing a number of challenges that need to be overcome in order for BCIs to become widely used during daily living. In this talk, I will focus on two such challenges: 1) having BCIs that allow performing a broad range o

…of cortical areas suggests that neural function may be built on the activation of population-wide activity patterns, the neural modes, rather than on the independent modulation of individual neural activity. These neural modes, the dominant covariation patterns within the neural population, define a low dimensional neural manifold that captures most of the

…of cortical areas suggests that neural function may be built on the activation of population-wide activity patterns, the neural modes, rather than on the independent modulation of individual neural activity. These neural modes, the dominant covariation patterns within the neural population, define a low dimensional neural manifold that captures m