In vitro assessment of the neural regenerative properties of regenerative macrophages (REMaST®)
Giulia Pruonto, Ludovica Sagripanti, Ilaria Barone, Alessia Amenta, Sissi Dolci, Eros Rossi, Loris Mannino, Francesca Ciarpella, Nicola Piazza, Benedetta Savino, Patrizia Bossolasco, Guido Francesco Fumagalli, Massimo Locati, Ilaria Decimo, Francesco Bifari · FENS Forum 2024
We successfully generated in vitro human regenerative macrophage self-trasplantation (REMaST®) derived from blood monocytes. Transcriptomic analysis of REMaST® confirm the upregulation, compared to M2 macrophages of neurogenic genes, and related to functions required to wound healing including, ECM-remodelling, angiogenesis, response to hypoxia, immune modulation, detoxification and defence, response to stress, and glucose metabolism. Therefore, we decided to exploit REMaST® neuro-regenerative potential and validate these properties. To evaluate REMaST® neurotrophic and neuroprotective activit
ePoster · Neuroscience