Topic: Neurexin-1

Mutations in the presynaptic adhesion protein Neurexin-1 (NRXN1) have been repeatedly implicated in cases of autism, schizophrenia, and ADHD. The excitation to inhibition (E:I) imbalance hypothesis posits that behaviours associated with neurodevelopmental disorders such as autism may be driven by the disturbed balance of excitation and inhibition in the cortex. We aimed to identify and characterise the effect of Neurexin-1 mutations on the E:I balance in autism-associated cortical circuits.To assess the effect of Nrxn1 alpha KO on synaptic transmission, whole-cell electrophysiological recordin