Functional 3D in vitro coculture model for assessing human neuro-glioma interactions
Nanna Förster, Lotta Isosaari, Oskari Kulta, Oona Junnila, Valtteri Vuolanto, Marjukka Pollari, Kirsi Rautajoki, Susanna Narkilahti · FENS Forum 2024
Gliomas, the heterogeneous primary brain tumors lacking efficient treatment, interact with their tumor microenvironment (TME) and the central nervous system (CNS) resident cells to support their own survival and growth. Deeper knowledge on these interactions is needed to improve treatment, and therefore glioma models incorporating components of human TME are of great interest. The aim of this work was to develop a three-dimensional (3D) in vitro coculture model for assessing physical and functional neuro-glioma interactions. For that, human glioblastoma cell line LN229/GFP-derived spheroids we
ePoster · Neuroscience