Electrophysiological correlates of neuroactive steroids treatment in the perinatal focal cerebral ischemia model in immature rats
Iqra Bano, Viera Kutna, Hana Chodounska, Eva Kudova, Grygoriy Tsenov · FENS Forum 2024
Conjugated 3α5β neuroactive steroids, such as allopregnanolone and pregnanolone, have garnered significant interest due to their potential therapeutic effects in various neurological conditions. Previously, the neuroprotective effect of 3α5β pregnanolone glutamate (3α5β-PG) was demonstrated in the model of focal cerebral ischemia in immature rats. The goal of this study was to determine electrophysiological correlates of ischemia-induced seizures and validate effects of 3α5β-PG treatment on seizure’s onset and EEG changes in twelve-day-old (P12) Wistar rats. Focal cerebral ischemia was induced
ePoster · Neuroscience