Molecular elucidation of lipofuscin in the aging brain and a rare pediatric dementia
Sofia Tieze, Alexander Esqueda, Matija Lagator, Rachel McAllister, Jean Kanyo, Florine Collin, TuKiet Lam, Kallol Gupta, Nicholas Lockyer, Sreeganga Chandra · FENS Forum 2024
Lipofuscin is an autofluorescent storage material that accumulates in the brain with normal aging. Lipofuscin deposition is also observed in numerous disease states but is most profound in neuronal ceroid lipofuscinoses (NCLs), a group of fatal neurodegenerative disorders that primarily affect children. Lipofuscin is known to be generally composed of proteins, lipids, metals, and carbohydrates, yet few specific lipofuscin constituents have been elucidated. Further, the spatiotemporal progression of lipofuscin accumulation in murine models remains unclear. An improved molecular and neuroanatomi
ePoster · Neuroscience