C-terminal binding protein 1 is necessary for normal migration of adult-born neurons
Burcu Sucu, Neeraja Suresh, Lena Marx, Enes Yağız Akdaş, Bartomeu Perelló-Amorós, Renato Frischknecht, Anna Fejtová · FENS Forum 2024
The C-terminal binding protein 1 (CtBP1) is a ubiquitously expressed, dual-function protein. In the nucleus, it nucleates corepressor complexes that control chromatin-modification and gene expression. In the cytoplasm, it regulates membrane trafficking processes by controlling the membrane fission reaction. Our previous study revealed an involvement of CtBP1 in the control of neural activity‐regulated genes such as BDNF, Arc and Fos in the mature brain. Recently, individuals with a missense mutation in CTBP1 have been reported to have intellectual disability and neurodevelopmental problems. Th
ePoster · Neuroscience