Regulatory network of forebrain development modeled in organoids reveals key factors associated with excitatory neurons imbalance in idiopathic autism
Alexandre Jourdon, Jessica Mariani, Feinan Wu, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Alexej Abyzov, Flora Vaccarino · FENS Forum 2024
Charting the regulatory interactions between transcription factors (TFs), enhancers, and genes during the formation of neuronal lineages in human can help decipher the complex genetic etiologies of neurodevelopmental disorders such as autism spectrum disorder (ASD). To achieve this, we conducted an integrative analysis of epigenomic and transcriptomic profiles of human forebrain organoids derived from individuals with idiopathic ASD and their neurotypical fathers. This multi-omics profiling allowed us to build an enhancer-driven gene regulatory network of early neural development and relate it
ePoster · Neuroscience