The impact of neurodegeneration on the electrical activity of brain tissue: Multielectrode array analysis
Andrijana Angelovski, Barbora Liščáková, Olga Švecová, Hana Hříbková, Jiří Sedmík, Dáša Bohačiaková, Petr Klimeš, Martina Kolajová, Milan Brázdil, Markéta Bébarová · FENS Forum 2024
Alzheimer's disease (AD) is characterized by neurodegeneration due to an accumulation of abnormal amounts of neurodegenerative proteins (NP). Elevated levels of NP have also been observed in patients suffering from temporal lobe epilepsy (TLE) which brings neurodegeneration into association with an increased risk of epileptic seizures. This study aimed to provide pilot data on the possible relationship between excitability and neurodegeneration. Electrical activity was recorded at 37°C using the multielectrode array (MEA) technique in cerebral organoids prepared from induced pluripotent stem c
ePoster · Neuroscience