Expression of angiotensin II receptors within hypothalamus-pituitary-adrenal axis after injury at lower and higher thoracic spinal level
Erika Hvozdíková, Veronika Liptáková, Jana Snopková, Erika Kellerová, Jaroslav Pavel · FENS Forum 2024
Traumatic spinal cord injury (SCI) leads to the immediate activation of the hypothalamus-pituitary-adrenal (HPA) axis. However, its proper function is impaired due to primary and secondary injury to the neural pathways of the sympathetic nervous system innervating the adrenal gland. Disruption of sympathetic innervation can strongly influence the expression of Angiotensin II receptors that are found at all levels of HPA axis. In this study, circulating Angiotensin II levels and the expression of Angiotensin II receptors within HPA axis after compression-induced SCI (40g weight for 15 min) at t
ePoster · Neuroscience