Topic: neurofibromin 1

Neurofibromatosis type I is a monogenetic disorder resulting from a defective copy of the neurofibromin 1 gene. Patients display a complex and varied clinical presentation which may include frequent tumour formation, hyperpigmentation marks, vision disorders and scoliosis. In addition, learning difficulties and psychiatric conditions such as ADHD, autism, anxiety or depression affect the majority of NF1 patients, and these symptom complexes are not addressed by standard therapeutic strategies. Here we employed a mouse model of NF1, the heterozygous Nf1 +/- mouse line. The initial approach invo