Exacerbation of tauopathy following mild and repeated spinal contusions in the hTauP301S mouse model
Nicolas Halloin, Kathleen De Swert, Lindsay Sprimont, Valéry Bielarz, Kunie Ando, Karelle Leroy, Charles Nicaise · FENS Forum 2024
Chronic traumatic encephalopathy is a tauopathy resulting from repeated moderate-to-severe traumatic injuries onto the brain, leading to Tau protein abnormal posttranslational modifications, mislocalization, and deposits. Although the spinal cord shares a lot of structural and cellular similarities, most studies of CNS traumatic injuries were conducted onto the brain. In the present project, we emitted the hypothesis that repeated mild contusions onto the spinal cord could similarly exacerbate the tauopathy in a transgenic mouse expressing an aggregation-prone human mutated tau protein (hTauP3
ePoster · Neuroscience