Topic: neurogenic activation

After excitotoxic lesions, subsets of striatal astrocytes undergo spontaneous neurogenic activation, leading to the local generation of a large number of neuroblasts for at least six months post-lesion. However, the functional integration of the lesion-induced neurons remains unclear. Fate mapping and 3D reconstruction analyses reveal that striatal neuroblasts undergo a maturation process in which they initially organize in clusters, subsequently disperse as individual cells, and gradually attain complex morphologies, often exhibiting dendritic spines. These neurons fail to express typical mar