Exploring the function of the synaptic adaptor protein p140Cap in human excitatory neurons derived from iPSCs
Mario De Gregorio, Alessandro Morellato, Olga Teresa Bianciotto, Arianna Colombino, Beatrice Bersia, Zoe Lesti, Samuele Marro, Emilia Turco, Paola Defilippi · FENS Forum 2024
The aim of this work is to analyze the roles of the adaptor protein p140cap in human nervous system, at neuronal and synaptic levels, using induced neurons from human induced pluripotent stem cells (iPSCs). Studies on mice models have demonstrated how p140cap is involved in the regulation of synaptic functions, especially in the maturation, stabilization, and remodeling of dendritic spines. This protein is also implicated in plasticity phenomena, such as LTP, LTD, learning, and memory, due to its direct interaction with the GLUN2A subunit of NMDAR. The p140cap protein is encoded by the SRCIN1
ePoster · Neuroscience