Dual roles of neuronal and microglial P2X4 receptor in ALS
Sara Carracedo, Anne Fayoux, Sandra Dovero, Francesca Degiorgi-ichas, Ludovica Congiu, Charlotte Madore, Sandrine Bertrand, Eric Boué-Grabot · FENS Forum 2024
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a selective loss of motor neurons (MN). During ALS, ATP released by neurons and glial cells modulates the neuroglial interplay via activation of P2X receptors. Among these, P2X4 receptor, which is a non-selective cationic channel, has been recently involved in ALS pathogenesis. We found that both the absence of P2X4 or the increase of surface P2X4 using P2X4KO or non-internalized P2X4KI mice respectively, have a beneficial outcome in the SOD1 mice. This paradoxical output suggests a complex cell-role of P2X4 in
ePoster · Neuroscience