Exacerbation of Alzheimer’s neurodegeneration due to Aβ–NETosis cross-talk is rescued by G6PD pharmacological inhibition in neutrophils
Laura Marchetti, Chiara Giacomelli, Martina Nencioni, Allegra Coppini, Alina Sîrbu, Ana Koperniku, Vittoria Raffa, Corrado Priami, Daria Mochly-Rosen, Maria Letizia Trincavelli · FENS Forum 2024
Recent data propose that Alzheimer’s disease (AD) should be considered as a systemic disease with a strong immune component. However, direct targeting of the immune system contribution to AD has been so far minimally explored. Here, by using a systems biology approach based on network integration of text mining and genomic data, we identified glucose‐6‐phosphate dehydrogenase (G6PD) as a target that may modulate neutrophil function and, in turn, down-regulate the immune system related damage in AD. Pharmacological and siRNA modulation, performed in differentiated HL-60 cells and primary neutro
ePoster · Neuroscience