Cerebellar BDNF signaling downregulation and autistic-like traits: Insights from a cholesterol storage disorder mouse model
Greta Massa, Serena Camuso, Lucy Babicola, Roberta Stefanelli, Jessica Tiberi, Piergiorgio La Rosa, Maria Teresa Fiorenza, Sonia Canterini · FENS Forum 2024
The cerebellum is a multifunctional brain region, controlling various motor and non-motor behaviors. Alterations in its architecture/function contribute to neurodevelopmental disorders, including autism spectrum disorders. In Niemann-Pick C1 (NPC1) disease, a lysosomal lipid accumulation disorder, cerebellar granule cells (GCs) proliferation and migration are impaired, due to reduced levels of Shh and BDNF during early postnatal development, affecting cerebellar cytoarchitecture.Since GCs complete their differentiation in early postnatal life driven by BDNF signaling, establishing synaptic con
ePoster · Neuroscience