Topic: neuronal aging

Genetic reprogramming techniques have been used with increasing success to generate human neurons from adult somatic cells. Induced pluripotent stem cell (iPSC) derived neurons have been shown as an effective way to investigate normal and pathological neuronal development. Additionally, transcription factor-based direct conversion of fibroblasts into induced neurons (iNs) has been established. Such iNs have been shown to retain age-related epigenetic information of the donor and therefore are viewed as a more appropriate model system for studying human neuronal aging and related pathologies. I