Exploring neuroinflammation and neuronal Ca2+ excitability in an Alzheimer's disease mouse model
Martina Bedetta, Nelly Redolfi, Annamaria Lia, Nikita Arnst, Elisa Greotti, Simonetta Falzoni, Francesco Di Virgilio, Paola Pizzo · FENS Forum 2024
Alzheimer's Disease (AD) is the primary cause of dementia, characterized by irreversible neurodegeneration resulting in memory loss and cognitive decline. Growing evidence suggests that neuroinflammation plays a pivotal role in AD, with extracellular ATP (eATP) as one of the key players in this process. Our project aims at investigating whether eATP influences microglia activation, AD-associated neuroinflammation and neuronal Ca2+ excitability in an AD mouse model (B6.152H) expressing human PS2-N141I and APP Swedish mutations. We conducted experiments at various disease stages: pre- and post-A
ePoster · Neuroscience