Topic: neuronal engram

The neuronal engram created during fear learning relies on both, plasticity of the neuronal network for its formation and the stability for persistence. The allocation of neurons to a specific engram depends on their excitability. Molecules regulating the excitation / inhibition balance (E/I balance) in the brain are therefore considered key players in engram formation. Nogo-A has been shown to influence the E/I balance, restrict activity-dependent functional and structural plasticity and modulate learning and memory formation. However, whether Nogo-A controls the memory engram formation and t