Doublecortin mutation leads to alterations in mitochondria during hippocampal development
Alexandra Boitard, Sergeï Kruglik, Carmen Cifuentes-Diaz, Angèle Charial, Marika Nosten-Bertrand, Melissa Stouffer, Franck Sureau, Stéphanie Bonneau, Fiona Francis, Richard Belvindrah · FENS Forum 2024
In the developing hippocampus, once generated, the pyramidal neurons migrate along radial glia processes to form the complex CA regions. Therefore, it is critical to understand the mechanisms controlling neuronal motility, leading to coordinated neuronal function. Doublecortin (DCX) shows mutations in human lissencephaly and heterotopia associated with epilepsy and intellectual disability. In the Dcx mouse mutant, the CA3 pyramidal region in the hippocampus forms an abnormal double layer, typical of heterotopia. Consequently, the mutant mouse presents an increased susceptibility to epilepsy. S
ePoster · Neuroscience