Topic: neuronal hyperpolarization

Epilepsy affects around 50 million people worldwide, with approximately 30% of cases proving drug resistant. An alternative treatment for drug-resistant cases, called ketogenic diet (KD), leverages a carbohydrate poor diet, and has been pioneered in the early 20th century. We introduce a model of a population of quadratic integrate-and-fire neurons where the metabolic feedback associated with KD affects neuronal excitability. Our proposed mechanism for seizure control hinges on the presence of adenosine triphosphate (ATP)-dependent potassium channels, whose activity, in the absence of ATP, res