Role of PTEN in cortical stem cell lineage progression
Osvaldo Antonio Miranda Romero, Ximena Contreras, Florian Pauler, Mara Davaatseren, Nicole Amberg, Simon Hippenmeyer · FENS Forum 2024
The neocortex is an architecturally complex structure composed of a diverse population of neurons and glia. This well-defined structure and cellular diversity can be attributed to the tightly regulated and highly ordered cortical development program. PTEN mutations in humans typically result in severe macrocephaly, increased susceptibility to a variety of cancers, and Autism Spectrum Disorder (ASD). Here we explore the role of Pten in cortical development at single-cell resolution by utilizing Mosaic Analysis with Double Markers (MADM) to sparsely label and perturb Pten in our mouse model. We
ePoster · Neuroscience