Topic: neuronal insulin signaling

Aims: α-synuclein is a protein that is highly expressed in brain neurons. Its normal function is still unknown, but it is thought to be crucial to the onset of dementia with Lewy bodies (DLB). As of now, DLB cannot be sufficiently explained by mutations in the α-synuclein protein because there are so few α-synuclein mutations found in DLB. Nevertheless, several studies have revealed that individuals with DLB also co-exhibit Aβ accumulation in the brain, suggesting that Aβ could be involved in α-synuclein neurotoxicity. However, the exact molecular mechanism behind Aβ-induced α-synuclein toxici