Topic: neuronal membrane time-scale

This study takes an analytic approach to delve into the dynamics of pyramidal neurons, focusing on interplay of the basal and perisomatic regions. A significant portion of recurrent excitatory connections converge onto the basal dendrites, generating N-Methyl-D-Aspartate (NMDA) driven depolarizations, also known as NMDA-spikes. The time-scale of NMDA-spikes significantly surpasses the neuronal membrane time-scale by a factor of five, underscoring their relevance in information integration. The voltage dynamics within the dendric subunits remain unaffected by somatic spikes, enabling their inde