Network plasticity and GABAergic cellular dynamics in the different layers of the somatosensory cortex after a spinal cord injury
Marta Zaforas, Elena Fernández-López, Elena Alonso-Calviño, Andrea Misol-Ortiz, Juan Aguilar · FENS Forum 2024
Thoracic complete Spinal Cord Injury (Th-SCI) produces physiological changes in the hindlimb somatosensory cortex (S1HL), which we have characterized as neuronal network hyperexcitability. Moreover, we have found a decreased GAD67 labeling intensity in the infragranular layers of S1HL in chronic Th-SCI. However, it is unknown how decreased labeling of GAD67 could be related to altered inhibitory function of GABAergic interneurons across cortical layers after SCI. The present work has two aims: characterize the physiological effect of a chronic Th-SCI over the different GABAergic neuronal popul
ePoster · Neuroscience