Topic: neuronal network signaling

Microelectrode arrays (MEAs) for non-invasive electrical readout of neurons are a valuable tool for long-term studies of neuronal network signaling on a single-cell level. However, conventional MEAs are built only in 2D and thus do not represent the three-dimensional network topology of the human brain. Here, we present an approach to equip planar MEAs with 3D microscaffolds featuring circuitry for enabling three-dimensional brain-on-a-chip devices with single-cell outgrowth control and electrical readout. Recently, we presented non-functional microscaffolds prepared by 3D nanoprinting (3DN) f