Characterization of CA2 oscillatory activity in social memory in a non-transgenic model of early Alzheimer’s disease in female and male mice
Raquel Jiménez Herrera, Ana Contreras, Juan D. Navarro López, Lydia Jiménez Díaz · FENS Forum 2024
Alzheimer’s disease (AD) early stages are characterized by amyloid beta oligomers (oAβ) toxicity in the hippocampus, leading to its dysfunction. Previously, we characterized a non-transgenic mouse model of early amyloidosis by a single intracerebroventricular (icv.) injection of oAβ1-42, that showed deficient hippocampal-dependent memory and synaptic plasticity impairment in the CA1–CA3 synapse regardless the sex. Social memory impairments have also been described in AD. However, neuronal oscillatory activity in hippocampal CA2 subfield, a region that plays a crucial role in the formation and
ePoster · Neuroscience