Rodent propionic acid model of autism: Synaptic architecture of the hippocampus and prefrontal cortex
Mzia Zhvania, Nadezhda Japaridze, Giorgi Lobzhanidze, Nino Pochkhidze, Pikria Khomasuridze · FENS Forum 2024
It is known that propionic acid (PPA) administration in rodents provokes multidirectional responses that are reminiscent to those observed in autism. However, whether PPA affects the ultrastructure/synaptic architecture of regions of autistic brain has not been adequately elucidated. In the present research, we used electron microscopic analysis to evaluate the effect of single intraperitoneal injection of moderate dose of PPA (175 mg/kg) on the ultrastructure of the hippocampus and medial prefrontal cortex of male adolescent Wistar rats. Furthermore, using morphometric electron microscopic ap
ePoster · Neuroscience